670 research outputs found
Small herbaria contribute unique biogeographic records to county, locality, and temporal scales
With digitization and data sharing initiatives underway over the last 15 years, an important need has been prioritizing specimens to digitize. Because duplicate specimens are shared among herbaria in exchange and gift programs, we investigated the extent to which unique biogeographic data are held in small herbaria vs. these data being redundant with those held by larger institutions. We evaluated the unique specimen contributions that small herbaria make to biogeographic understanding at county, locality, and temporal scales
Power analysis in health policy and systems research: A guide to research conceptualisation
Power is a growing area of study for researchers and practitioners working in the field of health policy and systems research (HPSR). Theoretical development and empirical research on power are crucial for providing deeper, more nuanced understandings of the mechanisms and structures leading to social inequities and health disparities; placing contemporary policy concerns in a wider historical, political and social context; and for contributing to the (re)design or reform of health systems to drive progress towards improved health outcomes. Nonetheless, explicit analyses of power in HPSR remain relatively infrequent, and there are no comprehensive resources that serve as theoretical and methodological starting points. This paper aims to fill this gap by providing a consolidated guide to researchers wishing to consider, design and conduct power analyses of health policies or systems. This practice article presents a synthesis of theoretical and conceptual understandings of power; describes methodologies and approaches for conducting power analyses; discusses how they might be appropriately combined; and throughout reflects on the importance of engaging with positionality through reflexive praxis. Expanding research on power in health policy and systems will generate key insights needed to address underlying drivers of health disparities and strengthen health systems for all
Effect of Advanced HIV Infection on the Respiratory Microbiome
RATIONALE:
Previous work found the lung microbiome in healthy subjects infected with HIV was similar to that in uninfected subjects. We hypothesized the lung microbiome from subjects infected with HIV with more advanced disease would differ from that of an uninfected control population.
OBJECTIVES:
To measure the lung microbiome in an HIV-infected population with advanced disease.
METHODS:
16s RNA gene sequencing was performed on acellular bronchoalveolar lavage (BAL) fluid from 30 subjects infected with HIV with advanced disease (baseline mean CD4 count, 262 cells/mm(3)) before and up to 3 years after starting highly active antiretroviral therapy (HAART) and compared with 22 uninfected control subjects.
MEASUREMENTS AND MAIN RESULTS:
The lung microbiome in subjects infected with HIV with advanced disease demonstrated decreased alpha diversity (richness and diversity) and greater beta diversity compared with uninfected BAL. Differences improved with HAART, but still persisted up to 3 years after starting therapy. Population dispersion in the group infected with HIV was significantly greater than in the uninfected cohort and declined after treatment. There were differences in the relative abundance of some bacteria between the two groups at baseline and after 1 year of therapy. After 1 year on HAART, HIV BAL contained an increased abundance of Prevotella and Veillonella, bacteria previously associated with lung inflammation.
CONCLUSIONS:
The lung microbiome in subjects infected with HIV with advanced disease is altered compared with an uninfected population both in diversity and bacterial composition. Differences remain up to 3 years after starting HAART. We speculate an altered lung microbiome in HIV infection may contribute to chronic inflammation and lung complications seen in the HAART era
Unusual raptor nests around the world
From surveys in many countries, we report using unusual nesting materials (e.g., paper money, rags, metal, antlers, and large bones) and unusual nesting situations. For example, we documented nests of Steppe Eagles [Aquila nipalensis] and Upland Buzzards [Buteo hemilasius] on the ground beside well-traveled roads, Saker Falcon [Falco cherrug] eyries in attics and a cistern, and Osprey [Pandian haliaetus] nests on the masts of boats and on a suspended automobile. Other records include a Golden Eagle [A. chrysaelos] nest 7.0 m in height, believed to be the tallest nest ever described, and, for the same species, we report nesting in rudimentary, nests. Some nest sites are within a Few meters of known predators or competitors. These unusual observations may be important in revealing the plasticity of a species' behavioral repertoire
The First Quiescent Galaxies in TNG300
We identify the first quiescent galaxies in TNG300, the largest volume of the
IllustrisTNG cosmological simulation suite, and explore their quenching
processes and time evolution to z=0. We find that the first quiescent galaxies
with stellar masses M_* > 3 x 10^{10} M_sun and specific star formation rates
sSFR < 10^{-11} yr^{-1} emerge at z~4.2 in TNG300. Suppression of star
formation in these galaxies begins with a thermal mode of AGN feedback at z~6,
and a kinetic feedback mode acts in each galaxy by z~4.7 to complete the
quenching process, which occurs on a time-scale of ~0.35 Gyr. Surprisingly, we
find that the majority of these galaxies are not the main progenitors of their
z=0 descendants; instead, four of the five galaxies fall into more massive
galaxies in subsequent mergers at a range of redshifts 2.5 < z < 0.2. By z=0,
these descendants are the centres of galaxy clusters with average stellar
masses of 8 x 10^{11} M_sun. We make predictions for the first quenched
galaxies to be located by the James Webb Space Telescope (JWST).Comment: 6 pages, 4 figure
JWST Reveals Widespread AGN-Driven Neutral Gas Outflows in Massive z ~ 2 Galaxies
We use deep JWST/NIRSpec R~1000 slit spectra of 113 galaxies at 1.7 < z <
3.5, selected from the mass-complete Blue Jay survey, to investigate the
prevalence and typical properties of neutral gas outflows at cosmic noon. We
detect excess Na I D absorption (beyond the stellar contribution) in 46% of
massive galaxies ( M/M 10), with similar incidence rates in
star-forming and quenching systems. Half of the absorption profiles are
blueshifted by at least 100 km/s, providing unambiguous evidence for neutral
gas outflows. Galaxies with strong Na I D absorption are distinguished by
enhanced emission line ratios consistent with AGN ionization. We conservatively
measure mass outflow rates of 3 - 100 yr; comparable to or
exceeding ionized gas outflow rates measured for galaxies at similar stellar
mass and redshift. The outflows from the quenching systems
(log(sSFR)[yr] -10) have mass loading factors of 4 - 360, and
the energy and momentum outflow rates exceed the expected injection rates from
supernova explosions, suggesting that these galaxies could possibly be caught
in a rapid blowout phase powered by the AGN. Our findings suggest that
AGN-driven ejection of cold gas may be a dominant mechanism for fast quenching
of star formation at z~2.Comment: 16 pages, 8 figures, submitted to MNRA
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Predictors of Enteric Pathogens in the Domestic Environment from Human and Animal Sources in Rural Bangladesh.
Fecal indicator organisms are measured to indicate the presence of fecal pollution, yet the association between indicators and pathogens varies by context. The goal of this study was to empirically evaluate the relationships between indicator Escherichia coli, microbial source tracking markers, select enteric pathogen genes, and potential sources of enteric pathogens in 600 rural Bangladeshi households. We measured indicators and pathogen genes in stored drinking water, soil, and on mother and child hands. Additionally, survey and observational data on sanitation and domestic hygiene practices were collected. Log10 concentrations of indicator E. coli were positively associated with the prevalence of pathogenic E. coli genes in all sample types. Given the current need to rely on indicators to assess fecal contamination in the field, it is significant that in this study context indicator E. coli concentrations, measured by IDEXX Colilert-18, provided quantitative information on the presence of pathogenic E. coli in different sample types. There were no significant associations between the human fecal marker (HumM2) and human-specific pathogens in any environmental sample type. There was an increase in the prevalence of Giardia lamblia genes, any E. coli virulence gene, and the specific E. coli virulence genes stx1/2 with every log10 increase in the concentration of the animal fecal marker (BacCow) on mothers' hands. Thus, domestic animals were important contributors to enteric pathogens in these households
Structural Evolution in Massive Galaxies at z ~ 2
We present 0.2arcsec-resolution Atacama Large Millimeter/submillimeter Array
observations at 870 m in a stellar mass-selected sample of 85 massive
() star-forming galaxies (SFGs) at z=1.9-2.6
in the 3D-HST/CANDELS fields of UDS and GOODS-S. We measure the effective
radius of the rest-frame far-infrared (FIR) emission for 62 massive SFGs. They
are distributed over wide ranges of FIR size from 0.4 kpc to
6 kpc. The effective radius of the FIR emission is smaller
by a factor of 2.3 than the effective radius of the optical
emission and by a factor of 1.9 smaller than the half-mass
radius. Even with taking into account potential extended components, the FIR
size would change by ~10%. By combining the spatial distributions of the FIR
and optical emission, we investigate how galaxies change the effective radius
of the optical emission and the stellar mass within a radius of 1 kpc,
. The compact starburst puts most of massive SFGs on the
mass--size relation for quiescent galaxies (QGs) at z~2 within 300 Myr if the
current star formation activity and its spatial distribution are maintained. We
also find that within 300 Myr, ~38% of massive SFGs can reach the central mass
of , which is around the boundary between
massive SFGs and QGs. These results suggest an outside-in transformation
scenario in which a dense core is formed at the center of a more extended disk,
likely via dissipative in-disk inflows. Synchronized observations at ALMA 870
m and JWST 3-4 m will explicitly verify this scenario.Comment: 25 pages, 15 figures, 3 tables, accepted for publication in Ap
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